Free vs Paid · 2026
One peptide calculator charges a one-time fee and runs on iOS only. The other is free, runs on iOS and Android, and has more features. Here's the honest comparison.
The Direct Comparison
| Feature | Protocol — Free | PeptideCalc — Paid |
|---|---|---|
| Reconstitution calculator | ✓ Full | ✓ Full |
| Custom Draw reverse mode | ✓ Unique | ✗ |
| PK half-life plotter | ✓ 22 compounds | Basic only |
| TRT ester calculator | ✓ | ✗ |
| Stack cost calculator | ✓ Only free one | ✗ |
| Android support | ✓ | ✗ |
| Titration preview | ✓ | ✓ Strong |
| iCloud sync | ✗ | ✓ |
| iPad support | ✗ | ✓ |
| Custom themes | ✗ | ✓ |
| Price | Free | One-time purchase |
The Honest Assessment
PeptideCalc's one-time purchase model is genuinely appealing — no subscription anxiety, pay once and use indefinitely. The titration preview is well-designed and shows dose escalation clearly before you commit to a schedule. iCloud sync across iPhone and iPad is useful if you use both devices. The custom theme system and cleaner visual design reflect real care for the user experience.
If you prefer one-time payments, primarily use an iPad, or want iCloud sync across devices, PeptideCalc has a defensible case. The calculation accuracy is comparable to Protocol's — both use the same underlying reconstitution math.
Protocol includes four calculation tools that PeptideCalc does not: Custom Draw reverse mode (specify syringe units, get BAC water amount), a PK half-life plotter for 22 compounds with multi-curve superposition, a TRT ester calculator showing free testosterone content per ester, and a stack cost calculator. Each of these solves a real calculation problem that PeptideCalc leaves to mental math or a spreadsheet.
Protocol also runs on Android — PeptideCalc does not. For the roughly half of smartphone users on Android, Protocol is the only full-featured peptide calculator available natively.
The one-liner
If you need iCloud sync and iPad support and are happy on iOS, PeptideCalc is worth evaluating. If you need Custom Draw, Android, or more than basic reconstitution, Protocol is the clear choice.
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